Senior Scientist – Downstream Analytics CV-Library Senior Scientist - Downstream Analytics

Scienceabode; Southampton; On-site; GBP 45,000 - 50,000; Full time

Job summary

An innovative scientific organisation in Southampton is seeking a Senior Scientist – Downstream Analytics to manage analytical workflows for nucleic acids and peptides. The role requires strong HPLC and bioprocessing expertise, a PhD or equivalent in a relevant field, and the ability to mentor junior staff. The position involves collaboration across disciplines, method development, and maintaining high quality standards. This is a hands-on role offering a salary of up to £50,000, along with comprehensive benefits including flexible hours and life assurance.

Benefits

25 days annual leave + 8 bank holidays

Pension with 6% employer contribution

Life Assurance: 4x salary

Flexible working hours

Bike to work scheme

Gym discounts

Qualifications

• Strong hands-on experience in HPLC and bioprocessing within a biotechnology or pharmaceutical environment.
• Knowledge of purification and characterisation methods for peptides and antibodies.
• Experience with ISO or GMP-regulated environments.

Responsibilities

• Lead downstream analytical workflows using HPLC, UPLC, and related techniques.
• Contribute to the purification and characterisation of large molecules.
• Support method development and continuous improvement.

Skills

HPLC

Bioprocessing

Analytical Chemistry

Problem-solving skills

Communication skills

Education

PhD in Analytical Chemistry, Biochemistry, or a related field

Tools

UPLC

PAGE

Tangential Flow Filtration (TFF)

Job description

Senior Scientist – Downstream Analytics (Large Molecules)

Biotech | HPLC | Bioprocessing | Southampton | Up to £50,000 + Benefits

We’re partnering with an innovative scientific organisation to recruit a Senior Scientist with strong experience in downstream analytical processes, including HPLC and bioprocessing techniques, to join a high-performing team based in Southampton. This hands‑on role offers the chance to support the development of modified nucleic acids and peptides, drive analytical method development, and contribute to the advancement of large molecule therapeutics in a collaborative, fast‑paced environment.

About the Role

You’ll take the lead on analytical workflows for nucleic acids, peptides, and antibodies, ensuring high standards of quality, compliance, and scientific rigour. The role will include method development, instrument maintenance, and cross-functional collaboration across R&D and production teams.

This position is ideal for a scientist who enjoys working across disciplines, mentoring junior colleagues, and staying at the forefront of analytical innovation.

Key Responsibilities

• Lead downstream analytical workflows using HPLC, UPLC, PAGE, flash chromatography, and related techniques
• Contribute to the purification and characterisation of large molecules, such as peptides and antibodies
• Support method development and continuous improvement in analytical approaches
• Collaborate with chemistry and production teams to support small molecule and oligonucleotide preparation
• Maintain, calibrate, and optimise analytical instrumentation in line with ISO and internal quality systems
• Mentor and support Associate Scientists and Lab Technicians
• Ensure accurate documentation and maintain data integrity across workflows
• Promote and uphold Health, Safety, and Environmental (HSE) standards
• Manage stock levels of analytical reagents and consumables
• Stay up to date on emerging trends in bioprocessing and analytical technologies

About You

We’re looking for a motivated and collaborative scientist with a solid grounding in downstream analytical techniques and a passion for quality science.

You’ll ideally have:

• A PhD (or equivalent experience) in Analytical Chemistry, Biochemistry, or a related field
• Strong hands‑on experience in HPLC and bioprocessing within a biotechnology, pharmaceutical, or life sciences environment
• Knowledge of purification and characterisation methods for peptides, antibodies, or similar large molecules
• Experience with TFF or tangential flow filtration (advantageous)
• Familiarity with ISO or GMP-regulated environments
• Ability to lead technical projects and support team development
• Strong communication and problem-solving skills
• A flexible, proactive mindset with strong attention to detail

Salary & Benefits

Salary: Up to £50,000 depending on experience

Location: On-site in Southampton

Holidays: 25 days annual leave + 8 bank holidays

Pension: 6% employer contribution

Life Assurance: 4x salary

Additional Benefits Include:

• Flexible working hours
• Long service awards and recognition scheme
• Employee Assistance Programme with 24/7 remote GP access
• Annual flu vaccinations
• Cycle to work scheme and gym discounts
• Discounts and savings platform
• Professional membership reimbursement
• Referral incentives
• Social events and volunteering days

£45000 – £50000/annum