Neuroscientist

Arnatar; Cardiff; On-site; GBP 40,000 - GBP 60,000; Full time

Job summary

A biotechnology company in Cardiff is seeking a Scientist focused on Antisense Therapeutics and Neuroscience. The role involves driving preclinical development of RNA-based therapies for neurological disorders, including study design and CNS model development. Ideal candidates will have a Ph.D. or M.S. in Neuroscience with relevant experience in drug delivery and CNS models. The company offers competitive compensation and opportunities for professional growth.

Benefits

Competitive compensation

Benefits

Opportunities for professional growth

Qualifications

• Ph.D. in Neuroscience or M.S. with industry experience required.
• Experience in neurological disease research.
• Strong background in CNS disease models.

Responsibilities

• Design and execute studies on antisense oligonucleotides.
• Develop CNS models for validation and testing.
• Collaborate with MedChem for ASO delivery optimization.

Skills

Neuroscience expertise

CNS delivery methods

Communication skills

Experimental design

Education

Ph.D. in Neuroscience or related discipline

M.S. in Neuroscience with ≥5 years of industry experience

Tools

Molecular assays (qPCR, Western blot, etc.)

Small animal handling

Job description

Arnatar is a biotechnology company located in San Diego, CA, we are developing antisense oligonucleotide (ASO) therapeutics to precisely modulate gene expression. Using a research-driven platform that integrates RNA biology, chemistry, and preclinical development, we design targeted drug candidates for diseases with high unmet need. Our mission is to advance innovative RNA-based medicines with the potential for meaningful, durable patient impact. Currently we are seeking an

Scientist – Antisense Therapeutics / Neuroscience.

About the Role

Arnatar Therapeutics is seeking a highly motivated Scientist with expertise in neuroscience, antisense oligonucleotide (ASO) therapeutics and CNS delivery to join our growing R&D team. The successful candidate will drive discovery and preclinical development of RNA-based therapies for neurological disorders.

You will play a key role in early drug discovery through target identification, designing experiments, developing disease models, and optimizing ASO delivery to the central nervous system (CNS) for neurological diseases. This is an exciting opportunity to contribute directly to our mission of creating transformative treatments for patients with unmet medical needs.

Key Responsibilities

• Design, execute, and interpret studies evaluating antisense oligonucleotides in neurodegenerative and neurodevelopmental disease models.
• Develop and characterize in vitro and in vivo CNS models for target validation and efficacy testing.
• In collaboration with MedChem and Biology departments, optimize delivery routes for ASOs to the CNS, including intrathecal, intracerebroventricular, and systemic delivery.
• Collaborate across teams in biology and pharmacology to integrate findings and guide project direction.
• Maintain accurate documentation and present data in internal and external meetings.
• Stay current with emerging advancements in RNA therapeutics, CNS biology, and drug delivery technologies.

Qualifications

• Ph.D. in Neuroscience, Molecular Biology, or a related discipline, or M.S. in Neuroscience with ≥5 years of relevant industry experience.
• Experience in neurological disease or neuromuscular disease research.
• Strong background in neuroscience and CNS disease models.
• Strong hands-on experience in small animal handling, drug administration through IT, ISV, IP, IV, and SC injections.
• Familiarity with rodent behavioral models and neuroanatomical techniques.
• Experience with antisense oligonucleotides, siRNA, or related RNA-based modalities is preferred.
• Experience in biotech or pharmaceutical R&D is preferred.
• Proven experience in in vivo CNS delivery techniques and PK/PD analysis is preferred.
• Proficiency with molecular and cellular assays (qPCR, Western blot, immunohistochemistry, microscopy, etc.).
• Excellent communication, organization, and problem-solving skills.

Why Join Arnatar Therapeutics

• Be part of an innovative team advancing RNA-based therapies for diseases of the nervous system.
• Collaborate with experts across disciplines in a fast-paced, science-driven environment.
• Competitive compensation, benefits, and opportunities for professional growth.