Senior Scientist I - Analytical Development & Validation

Immunocore Ltd; Oxford; On-site; GBP 40,000 - GBP 80,000; Full time

Job summary

An innovative biotech company is seeking a Senior Scientist I to drive advancements in analytical development and validation. This role involves designing experimental investigations, developing chromatographic and electrophoretic methods, and leading assay qualification for TCR-based molecules. You will collaborate with teams to ensure accurate laboratory records and mentor colleagues. Join a pioneering organization dedicated to transforming patient lives through groundbreaking therapies, where your contributions will play a vital role in shaping the future of biopharmaceuticals.

Qualifications

• Experience in developing methods for recombinant proteins or antibodies.
• Expertise in chromatographic and electrophoretic techniques.

Responsibilities

• Conduct experimental investigations to advance the company's pipeline.
• Design and conduct chromatographic and immunoassay studies.

Skills

Chromatographic methods development

Electrophoretic methods development

Immuno-analytical techniques

Assay qualification/validation

Biopharmaceutical stability studies

Teamwork and initiative

Scientific presentation

Education

BSc in Biochemistry

MSc in Biotechnology

PhD in a related discipline

Job description

Job Details: Senior Scientist I - Analytical Development & Validation

Full details of the job.

Vacancy Name

Senior Scientist I - Analytical Development & Validation

Vacancy No

VN627

Employment Type

Permanent

Location of role

Oxford, UK

Department

CMC

Key Responsibilities

To conduct and design experimental investigations that advance the Company's pipeline, processes, or technologies, proposing improvements for review. Responsibilities include assay development and qualification for ImmTAX and other TCR-based molecules, overseeing method transfers to CDMOs, and leading investigational and CMC support packages.

1. Designing and conducting chromatographic, electrophoretic, and immunoassay development studies.
2. Supporting qualification of analytical methods per ICH guidelines.
3. Contributing to method transfers to CDMOs.
4. Leading studies on biologics/drug products, including comparability.
5. Writing protocols and reports.
6. Performing and leading investigations, proposing new experiments based on data.
7. Setting priorities for work and projects, making informed decisions.
8. Sharing technical knowledge and mentoring colleagues.
9. Ensuring accurate and timely laboratory records.
10. Providing guidance on equipment use and recommending new equipment.
11. Communicating research findings effectively.
12. Adhering to safety policies in laboratories.

Person Specification

Experience & Knowledge

Essential

• Experience in developing chromatographic and electrophoretic methods for recombinant proteins or antibodies.
• Experience working in a bench-based biopharmaceutical lab.
• Expertise in electrophoretic, chromatographic, or immuno-analytical techniques.
• Experience in assay qualification/validation.
• Knowledge of biopharmaceutical stability studies.
• Teamwork experience and initiative in improving work practices.
• Ability to present scientific findings and mentor colleagues.

Desirable

• Experience with late-stage/clinical biopharmaceutical assays.
• Knowledge of GMP principles.
• Experience presenting at external conferences.
• Participation in external collaborations.
• Project leadership experience.
• Understanding of analytical needs for clinical trial materials.

Education & Qualifications

• Essential: BSc or MSc in biochemistry, biotechnology, or related field.
• Desirable: PhD in a related discipline.

About the Company

Immunocore (NASDAQ: IMCR) is a pioneering T cell receptor biotech company developing transformative medicines for oncology, infectious, and autoimmune diseases. Our innovative soluble TCR platform and ImmTAX molecules aim to harness the immune system for broad medical applications. We foster an inclusive environment guided by our STRIDE values—Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship—dedicated to breakthrough therapies and transforming patient lives. Immunocore is an equal opportunity employer committed to diversity and inclusion.