Director Clinical Pharmacology

Glaxosmithkline Consumer Healthcare SA; Stevenage; Hybrid; GBP 188,000 - GBP 314,000; Full time

Job summary

A global biopharma company is seeking a Director of Clinical Pharmacology to lead innovation in Model-Informed Drug Development (MIDD). The role requires a PhD with significant experience in clinical pharmacology, focusing on drug development strategy and advancing regulatory readiness. The position promotes engagement across specialized teams and aims to enhance GSK's scientific leadership through impactful publications and cross-disciplinary partnerships.

Benefits

Health care and insurance benefits

Retirement benefits

Paid holidays and vacation

Qualifications

• PhD, MD, or PharmD with clinical pharmacology experience.
• Extensive experience in modelling and simulation in drug development.
• Experience in pharmacometrics applied to clinical questions.

Responsibilities

• Design & execute Model Informed and Clinical Pharmacology strategies.
• Draft and review clinical pharmacology regulatory content.
• Build cross-functional partnerships and share best practices.
• Raise GSK’s profile in clinical pharmacology through publications.

Skills

Experience in clinical pharmacology

Knowledge of modelling and simulation

Ability to solve practical problems

Collaboration in a multi-discipline team

Scientific leadership

Education

PhD in life sciences or related discipline

Job description

Director, Clinical Pharmacology

The Department of Clinical Pharmacology Modelling & Simulation Respiratory and Inflammation (CPMS R&I) at GSK is recruiting a director-level Clinical Pharmacologist.

This role is based in UK or US, with remote working or placement at other European GSK sites possible for the right candidate.

Job Purpose

The Director, Clinical Pharmacology sits within the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation, which aims to be a centre of excellence in Model‑Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging and mechanistic/systems modelling.

You will lead the end‑to‑end application of MIDD across the drug development lifecycle—from first‑in‑human studies through filing and lifecycle management—and provide clinical pharmacology strategy and evidence‑generation input. This is an opportunity to join a highly regarded, high‑impact team with a strong publication track record, reporting directly to the Respiratory, Immunology & Inflammation Research Unit (RIIRU).

Main Responsibilities

• Design & Execute Model Informed and Clinical Pharmacology strategies

Develop and implement robust MIDD & ClinPharm evidence strategies to de risk and accelerate RIIRU programs. Aim for faster development, optimal dosing and stronger regulatory positioning across respiratory, inflammation, neurodegeneration and emerging areas — and support business development opportunities.

• Ensure robust ways of working and regulatory ready evidence

Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling. Maintain up to date knowledge of FDA, EMA, CDE, PMDA and ICH expectations and embed regulatory considerations and best practices into study design and MIDD strategies.

• Build cross‑functional partnerships

Work closely with CPQM peers (digital medicine, translational imaging, MIDD specialists, mechanistic/systems modelling) and cross functional partners (biology, data science, computational biology, clinical, etc.). Maintain strong networks and share best practices in the CPMS community of practice. Build strong network key functions such as AI/ML, biomarkers, biostatistics, clinical operations, data science, computational biology and RWE to embed quantitative approaches into decision making at asset level.

• External engagement & scientific leadership

Raise GSK’s profile in MIDD, clinical pharmacology, QSP and AI/ML integration through publications, conference presentations and active participation in scientific and regulatory fora to influence method adoption and regulatory dialogue

Basic Qualifications

• PhD in life sciences or related discipline, MD, or PharmD, with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and development.
• Significant experience in clinical pharmacology, modelling/simulation and drug development to solve practical problems in the pharmaceutical industry.
• Experience in pharmacometrics and their application to clinical questions in drug development.

Preferred Qualifications3>

• Additional experience in respiratory and immunology would be beneficial.
• Demonstrated experience of collaboration in a multi‑discipline team, using effective communication and taking personal accountability for timely delivery of results.
• Evidenced experience making sound judgement in complex situations and adapting to changing business needs by prioritizing multiple tasks.
• Experience working with senior stakeholders in a cross functional environment.
• Track record of implementation of Model‑Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs.
• Drive and learning agility to build knowledge on a drug‑disease system, symptom progression, standard of care, and trial design.

*LI‑GSK#

• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $188,100 to $313,500.

The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share‑based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Equal Opportunity Employer

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at [e-mail] where you can also request a call.

Please note that if your enquiry does not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the Link where you will find answers to multiple questions we receive.

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