Principal Biostatistician (RWE Specialist - NA and Europe)

Syneos Health, Inc.; United Kingdom; On-site; GBP 70,000 - 90,000; Full time

Job summary

A global healthcare solutions provider seeks a Principal Biostatistician specialized in analyzing real-world data to support clinical trial design. The role requires prior experience in RWE/RWD and proficiency in statistical programming. Responsibilities include evaluating data quality, developing exploration plans, and collaborating with clinical and regulatory teams. Competitive benefits include health insurance, flexible PTO, and participation in the Employee Stock Purchase Plan.

Benefits

Company car or car allowance

Health benefits (medical, dental, vision)

401k company match

Eligibility for Employee Stock Purchase Plan

Flexible paid time off (PTO)

Qualifications

• Must have previous lead industry experience within RWE/RWD.
• Familiarity with licensed RWD databases is essential.
• Ability to clean and harmonize raw RWD for analysis.

Responsibilities

• Analyze in-house real-world data for clinical trial design.
• Critically evaluate data quality and suitability.
• Develop RWD exploration plans and new analytical tools.

Skills

RWD/RWE industry experience

SAS

R

Python

Data governance

Job description

Principal Biostatistician (RWE Specialist - NA and Europe)

Updated: November 5, 2025
Location: GBR-Remote
Job ID: 25103066

Job Summary

An RWE specialist role to analyze in-house real-world data (EHRs, claims, registries, etc.) and develop insights to support clinical trial design.

Job Responsibilities

• Must be located in NA or Europe. If in NA must be open to working EST hours.
• Previous lead industry experience within RWE/RWD is required.
• Understand and be familiar with licensed RWD databases; independently identify, access, and assess in-house real-world data sources (EHRs, claims, registries, etc.) relevant to clinical trial populations and endpoints.
• Access and summarize non-patient-level real-world data (publications, aggregate claims or EHR analytics, federated learnings, external collaborations, etc.) relevant to clinical trial populations and endpoints.
• Critically evaluate data quality, completeness, and suitability for specific trial design questions.
• Develop RWD exploration plans.
• Clean, process, and harmonize raw RWD for analysis, applying data governance and privacy standards.
• Use SAS, R, Python and/or other advanced analytical programming tools to perform statistical analyses and generate insights on patient characteristics, treatment patterns, outcomes, and epidemiology.
• Prepare clear, concise evidence summaries and visual reports to inform protocol development (inclusion/exclusion criteria, endpoints, comparator selection, feasibility assessments, etc.).
• Collaborate cross-functionally with clinical, regulatory, biostatistics, and medical teams.
• Stay current on RWD methodologies, regulatory guidance, and technological advances in the field.
• Ensure all work supports timely, high-quality decision making for new clinical trial design and execution.
• Develop new innovative RWD analytical tools where needed.

Benefits

Potential benefits may include a company car or car allowance, health benefits (medical, dental, vision), company match 401k, eligibility to participate in Employee Stock Purchase Plan, eligibility to earn commissions/bonuses, and flexible paid time off (PTO) and sick time.

Equal Opportunity Employer

Syneos Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, marital status, ethnicity, national origin, sex, gender, gender identity, sexual orientation, protected veteran status, disability or any other legally protected status and will not be discriminated against. If you have a disability that requires accommodation, contact [e-mail].

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