Postdoctoral Training Fellow in Hypoxia and Leukaemia Biology

The Institute of Cancer Research; Sutton; On-site; GBP 40,000 - GBP 60,000; Full time

Job summary

A leading cancer research institute in Sutton is seeking a Postdoctoral Training Fellow to advance research on leukaemic stem cells. This role requires a PhD in relevant fields and significant experience in cancer research. Responsibilities include investigating the cellular oxygen-sensing system in acute myeloid leukaemia and developing novel therapeutic strategies. The position offers a competitive salary and access to state-of-the-art facilities in a dynamic work environment.

Benefits

Dynamic and supportive research environment

Access to state-of-the-art facilities

Professional development opportunities

Competitive salary and pension

Qualifications

• PhD in hypoxia biology, biochemistry, cell biology, molecular biology, stem cell biology, oncology, or chemical biology.
• Significant experience in hypoxia biology/biochemistry, stem cell biology, and cancer research.
• Previous postdoctoral experience in hypoxia and/or leukaemia biology.

Responsibilities

• Investigate the impact of PHDs in AML biology and evaluate novel inhibitors.
• Develop effective treatments for leukaemic stem cells.

Skills

Hypoxia biology

Biochemistry

Cell biology

Stem cell biology

Oncology

Education

PhD in relevant field (hypoxia biology, biochemistry, etc.)

Job description

Overview

Postdoctoral Training Fellow in Hypoxia and Leukaemia Biology

Under the guidance of Professor Kamil Kranc, we are seeking to recruit a Postdoctoral Training Fellow to pursue therapeutic targeting of the cellular oxygen-sensing system in order to eliminate leukaemic stem cells in acute myeloid leukaemia (AML) and develop effective treatments for this disease.

Key Information

Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review.

Duration: Fixed term for 3 years

Hours per week: 35 hours per week (Full Time)

Location: Sutton

Closing Date: 2nd March 2026

This role is eligible for ICR Sponsorship. If this is your first visa in the UK, support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Responsibilities

The post holder will:

• Investigate how inactivation of PHDs and related enzymes impacts AML biology, identify AML subtypes sensitive to these interventions, evaluate novel small-molecule inhibitors in vivo, and discover synthetic lethal vulnerabilities and resistance mechanisms to inform optimal combination strategies and overcome therapeutic resistance.
• Contribute to therapeutic targeting of the cellular oxygen-sensing system to eliminate leukaemic stem cells in AML and develop effective treatments for this disease.

About you

The successful candidate must have:

• PhD in hypoxia biology, biochemistry, cell biology, molecular biology, stem cell biology, oncology or chemical biology.
• Significant experience in hypoxia biology/biochemistry, stem cell biology, and cancer research.
• Previous postdoctoral experience in hypoxia and/or leukaemia biology.

Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDT F at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years.

For general information on Postdocs at The ICR, more information can be found here.

Department/Directorate Information

The Haemato-Oncology Group specialises in understanding and targeting leukaemic stem cells, which are responsible for AML initiation, disease progression, relapse, and resistance to conventional therapies. Our group focuses on discovering cures for acute myeloid leukaemia with an aim to identify novel therapeutic targets for selective elimination of LSCs, without disrupting normal haematopoiesis.

What we offer

• A dynamic and supportive research environment
• Access to state-of-the-art facilities and professional development opportunities
• Collaboration with leading researchers in the field
• Competitive salary and pension

How to apply

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Kamil Kranc via email.

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles; please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

We champion diversity and welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.