Research Fellow in Structural Biology

University of Leeds; Leeds; On-site; GBP 41,000 - GBP 49,000; Full time

Job summary

A leading research university in the UK seeks a Research Fellow in Structural Biology with expertise in cryoEM/ET to investigate protein assembly and amyloid diseases. This position involves working in a collaborative interdisciplinary team on a Wellcome Discovery award project. The successful candidate will explore how changing assembly conditions alter amyloid fibril structures and their cellular impact. A PhD in Structural Biology is required, with opportunities for flexible working arrangements.

Qualifications

• Strong background in cryoEM/ET techniques for elucidating protein assembly.
• Experience in investigating amyloid fibril structures and their cellular impact.
• Ability to work collaboratively in an interdisciplinary research team.

Responsibilities

• Investigate how proteins aggregate into amyloid fibrils.
• Explore how changing assembly conditions alters fibril structures.
• Determine the role of fibril types in cellular dysfunction and disease.

Skills

Expertise in cryoEM/ET

Mechanistic studies of protein assembly

Biophysical analysis

Cell biological techniques

Education

PhD in Structural Biology (close to completion)

Job description

Research Fellow in Structural Biology (CryoEM/ET), Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences
Salary: Grade 7 (£41,064 - £48,822 p.a.)

This role will be based on the university campus. We are also open to discussing flexible working arrangements.

Are you an ambitious researcher looking for your next challenge? Do you have an established background in mechanistic studies of protein assembly using cryoEM/ET and want to help to develop new routes to combat amyloid disease? Do you want to further your career in one of the UK’s leading research-intensive Universities?

Understanding and Controlling Amyloid Polymorphism: From Test Tube to Tissue

We are looking for an outstanding research fellow to join our interdisciplinary team investigating how proteins aggregate into amyloid fibrils, and how fibrils with different structures perturb cellular function. This 6-year Wellcome Discovery award will involve three post-doctoral fellows and two PhD students, who will form an integrated team combining biochemical, biophysical, cell biological and structural methods (cryoEM and cryoET) with the goal of transforming our understanding of amyloid polymorphism in vitro and its consequences in cells, in mouse models and in human tissue. The project will focus on IAPP involved in type-2 diabetes and -synuclein in Parkinson’s disease. For this position we are seeking a talented postdoctoral researcher with expertise in cryoEM/ET of protein assemblies. You will use cryoEM/ET to explore how changing the assembly conditions alters the structures of amyloid fibrils, and how fibril structure and polymorphism change with time in vitro, in cells and in tissues. You will also determine the structures of fibrils extracted from murine and patient samples and determine the role of different fibril types in causing cellular dysfunction and disease. You will work closely with two other postdoctoral fellows funded on the grant who bring expertise in biophysical analysis of amyloid assembly and cell biological/imaging methods.

You will be based in the laboratories of Professors Sheena Radford and Neil Ranson , and work closely with other members of our amyloid team. For this position you should have (or be close to completing) a PhD in Structural biology (cryoEM/ET) to elucidate protein assembly mechanisms.

Salary Requirements of the Skilled Worker Visa Route

Please note that this post may be suitable for sponsorship under the Skilled Worker visa route but first-time applicants might need to qualify for salary concessions. For more information, please visit the Government’s Skilled Worker visa page .

To explore the post further or for any queries you may have, please contact:

Professor Sheena Radford, Astbury Professor of Biophysics

Professor Neil A Ranson, Professor of Structural Molecular Biology