Senior Scientist -Subject Matter Expert Mass Spectrometry (ATDBio)

Biotage AB; Southampton; On-site; GBP 40,000 - 60,000; Full time

Job summary

A global separations company in Southampton is seeking a Senior Scientist specializing in Mass Spectrometry to lead analytical strategies and ensure high-quality oligonucleotide production. The ideal candidate has a PhD in Analytical Chemistry and extensive experience in a high-throughput environment. This full-time role offers a supportive work culture and various employee benefits.

Benefits

25 days annual leave

Contributory pension scheme

Flexible working hours

Life Assurance

Corporate discount on gym membership

Qualifications

• Proven experience in high-throughput chemistry or oligonucleotide production.
• Hands-on experience with Mass Spectrometry.
• Ability to mentor junior staff and lead projects.

Responsibilities

• Lead analytical workflows involving LC-MS, HPLC, and UPLC-MS.
• Act as SME in Mass Spectrometry, driving method development.
• Ensure compliance with ISO and internal quality systems.

Skills

Mass Spectrometry

Analytical Chemistry

Nucleic Acid Chemistry

Leadership

Project Management

Education

PhD in Chemistry or Analytical Chemistry

Tools

Waters LC-MS Systems

Job description

Senior Scientist - Subject Matter Expert Mass Spectrometry (ATDBio)

Location: Southampton, United Kingdom

Department: Oligonucleotide Production

Join our high-performing Oligonucleotide Production Team in Southampton, where innovation meets excellence. We are seeking a Senior Scientist with deep expertise in Mass Spectrometry to lead analytical strategy and contribute to the development and production of high-quality modified oligonucleotides.

Responsibilities

• Lead and oversee analytical workflows involving LC-MS, HPLC, PAGE, UPLC-MS and related chromatography to support oligonucleotide synthesis and purification.
• Act as the subject matter expert (SME) in Mass Spectrometry, driving method development, troubleshooting, and continuous improvement initiatives.
• Collaborate cross-functionally to optimize small molecule preparation and oligonucleotide synthesis processes.
• Maintain and calibrate analytical instrumentation, ensuring high performance and compliance with quality standards.
• Provide technical leadership and mentorship to Associate Scientists and Lab Technicians, supporting training and development.
• Ensure rigorous documentation and data integrity in line with ISO and internal quality systems.
• Champion Health, Safety, and Environmental (HSE) standards and promote a culture of safety and compliance.
• Manage inventory and procurement of analytical reagents and consumables.
• Stay abreast of emerging technologies and methodologies in nucleic acid chemistry and analytical science.

Skills & Experience

• PhD in Chemistry, Analytical Chemistry, or a related discipline.
• Proven experience in a high-throughput chemistry or oligonucleotide production environment.
• Extensive hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Experience of Waters Connect is highly desirable).
• Strong background in nucleic acid chemistry and familiarity with purification techniques. Oligonucleotide experience is highly desirable.
• Demonstrated ability to lead projects, mentor junior staff, and influence scientific strategy.
• Experience working within ISO or GMP-regulated environments.
• Excellent problem-solving, communication, and organizational skills.
• Self-starter with the ability to work under pressure in a fast-changing environment; detail-oriented with strong communication skills.

What we can offer you

• 25 days annual leave plus 8 paid bank holidays
• Contributory pension scheme (6% employer contribution)
• Flexible working hours
• Life Assurance (x4 salary)
• Long service awards
• Reward and recognition scheme
• Employer Assistance Programme with 24/7 remote GP service
• Annual flu jabs
• Cycle to work scheme
• Corporate discount on gym membership
• Savings and discounts
• Reimbursement of professional membership fees
• Referral incentives
• Social events
• Volunteering days

About Biotage

Biotage is the Global Go-To Separations Company, supporting customers from drug discovery and development through to diagnostics and analytical testing with intelligent and sustainable workflow solutions. Headquartered in Sweden, Biotage operates globally with 700 employees, serving over 80 countries. Our company is listed on NASDAQ Stockholm (BIOT).

Seniority level

Mid-Senior level

Employment type

Full-time

Job function

Research, Analyst, and Information Technology

Note: This posting reflects a refined version of the original description for clarity and formatting adherence. No other content has been added beyond what was provided.