Senior Health Economics Manager / Associate Director Health Outcomes Research

MSD; Greater London; Hybrid; GBP 70,000 - GBP 90,000; Full time

Job summary

A leading pharmaceutical company in Moorgate, London, is seeking a Senior Health Economics Manager to lead HTA submissions to NICE and other health technology assessments. The role requires a Master's degree in Health Economics and experience in leading multiple HTA projects. Key responsibilities include developing market access strategies and guiding economic models. Candidates should possess strong analytical skills and a deep understanding of the NHS systems. The company offers a hybrid work model and commitment to professional development.

Benefits

Professional development and training opportunities

Supportive company culture

High autonomy in project development

Qualifications

• Experience of multiple HTA submissions, including NICE.
• Deep knowledge of NICE methods and processes.
• Understanding of NHS and payer systems in the UK.

Responsibilities

• Lead HTA submissions to NICE and other agencies.
• Develop market access tools for various stakeholders.
• Guide UK cost-effectiveness models and represent the company at meetings.

Skills

Accountability

Business Management

Data Analysis

Health Economics

Stakeholder Relationship Management

Education

Master's degree in Health Economics or related discipline

Tools

Complex datasets

Job description

Job DescriptionJoin one of the UK’s largest and most active HTA & Outcomes Research teams based in Moorgate, London and help secure national access to innovative medicines and vaccines.In this role, you will:* Lead and support HTA submissions to NICE, SMC, AWMSG, JCVI and NCPE* Develop market access tools and resources for national, regional and local use* Contribute to evidence generation with health economists, Evidence-Based Medicine managers and RWE expertsYou will work in a focused sub‑team within a global organisation, collaborating with UK cross‑functional colleagues and external stakeholders, all with a clear goal: improving patients’ lives. Our hybrid working model supports both effective teamwork and your ongoing development. **What you will do:** As a Senior Health Economics Manager, you will: * Lead the HTA process for a single technology or indication for both the health economic and clinical components, with particular focus on the suitability of the economic argument to support the HTA strategy* Develop and adapt materials and evidence generation activities to demonstrate the value of company assets under the JCVI’s remit (vaccines and other). They may also be required to respond to tenders issued by the DHSC* With support from a Team Lead, you will be responsible for optimising the submission strategy, ensuring the economic arguments are appropriate, robust consistent with the clinical data. The dossier must be of high quality and delivered on time. You will also lead post submission activities **National value assessment for medicines and vaccines** * Devise and lead UK & Ireland value assessment strategies, ensuring economic models and arguments support HTA objectives* Lead high‑quality HTA dossier development and the full assessment process (e.g. clarification questions, ACD responses), across both clinical and economic components* Guide UK cost‑effectiveness and budget impact models and input into evidence synthesis (e.g. SLRs, NMAs), including use of real‑world data to address evidence gaps* Manage external vendors (e.g. model adaptations, SLR/NMA work), ensuring strategic, technical and timeline standards are met* Shape global early models and clinical trial design to reflect UK & Ireland requirements and product value propositions* Represent the company at NICE and other HTA/JCVI meetings and advisory boards; engage with clinicians, payers, patient groups and other stakeholders to inform strategy* Work closely with cross‑functional and pricing colleagues to anticipate appraisal risks and opportunities and ensure alignment across internal and external stakeholders **Evidence generation** * Lead evidence generation activities that address gaps particularly of relevance to HTA/JCVI dossiers* Support generation of economic evidence to support lifecycle management, uptake and implementation of novel treatments* Contribute to and/or lead health economic methodological research initiatives (e.g. NICE Methods, key issues in oncology modelling) **Lifecycle management** * Conduct landscape assessments for products in the pipeline, focusing on HTA and health economic risks and mitigations* Support New Product Planning colleagues to ensure that HTA requirements are anticipated in the development of UK launch plans* As required, ensure all necessary horizon scanning is up to date* Contribute to cross-functional strategy sessions with medical, marketing, market access, and external affairs colleagues **Development, building capability, compliance, routine business activities** * Contributing to the development of technical expertise both within the HTA & OR team and the broader company* Keep up to date on best practice statistical and health economic methods, clinical trial design and reporting* Coach and mentor health economics managers in the team on technical methods* There may be opportunities to manage summer and annual interns**Qualifications, Skills & Experience Required:** * Master's degree in Health Economics or related discipline* Experience of multiple HTA submissions (should include NICE), including all process milestones* Deep knowledge of NICE methods and processes, strong economic modelling knowledge and experience, knowledge of evidence synthesis and outcomes research methods.* A deep understanding of the NHS and payer systems in the UK **Competencies/Skills:** * Excellent communication skills (verbal and written as well as presentation skills)* Quantitative and statistical literacy; comfortable working with complex datasets and assumptions; excellent analytical skills* Working collaboratively in a matrix organization* Strong organisational and prioritisation skills across multiple concurrent projects* Proven ability to lead end‑to‑end HTA projects to tight timelines and high quality**What we offer:*** The opportunity to be involved in a broad range of therapy areas and a large volume of submission work* High levels of autonomy and ownership in developing HTA submission dossiers in-house* Involvement in the end-to-end HTA work, from clinical trial design to post-HTA approval* Membership of a global organisation and collaboration with colleagues around the world* Have the chance to influence global and local decision making that impacts the lives of thousands of people* A supportive and positive company culture* Professional development and training opportunitiesYour role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement.We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.**Closing date: 22nd February 2026****Required Skills:**Accountability, Business Management, Business Operations, Clinical Trials, Consumer Relations, Cross-Functional Collaboration, Customer Engagement, Data Analysis, Data Management, Economic Analysis, Health Economics, Inclusive Leadership, Outcomes Research, Researching, Scientific Research, Stakeholder Relationship Management, Strategic Planning, Value Propositions**Preferred Skills:**Current Employees applyCurrent Contingent Workers apply**Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.**Employee Status:**Regular**Relocation:****VISA Sponsorship:****Travel Requirements:****Flexible Work Arrangements:**Hybrid**Shift:****Valid Driving License:****Hazardous Material(s):****Job Posting End Date:**02/23/2026**\*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.**