Analytical Scientist (Biotechnology/LNP & Lipid Analytics)

Neovac; East Hagbourne; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading biotech company in the UK seeks an Analytical Scientist to develop and validate analytical methods for lipids and polymers. The role demands strong laboratory skills and proficiency in HPLC techniques. Candidates must have a Master's degree and at least 3 years of hands-on experience in an industry setting. You'll support cross-functional teams and collaborate with external partners. This position offers a chance to contribute to innovative drug development in a dynamic and growing environment.

Qualifications

• 3+ years hands-on experience with HPLC in industry, preferably in pharma/biotech.
• Demonstrated proficiency with HPLC-CAD and hands-on experience with LC-MS.
• Proven track record of independently validated cGMP methods.

Responsibilities

• Develop and validate analytical methods for lipids and polymers.
• Troubleshoot analytical methods and perform routine analyses.
• Support external CROs and GMP partners as needed.

Skills

HPLC expertise

Strong problem-solving abilities

Analytical method development

Collaboration skills

Education

Master’s degree in Chemistry or related field

Tools

HPLC-CAD

HPLC-UV

LC-MS

Job description

NeoVac is building a new ground-breaking LNP platform to deliver better mRNA vaccines and treatments for various diseases. At NeoVac, we envision a world where mRNA vaccines and treatments are available to everyone and everywhere.

We are applying science and technology to address some of the most serious conditions affecting humanity, including increasing antibiotic resistance, cancer, and viral illnesses. We aspire to be the leading life science company in this field.

RESPONSIBILITIES & DUTIES

As an Analytical Scientist, you will be responsible for the development, optimisation, and validation of analytical methods to characterise lipids, PEG‑polymers, nanoparticle components, process intermediates, and final drug substances.

You will work closely with formulation chemistry, RNA teams, and manufacturing partners to support drug development from discovery through early GMP stages.

This role requires strong laboratory autonomy, problem‑solving capabilities, and a passion for high‑quality data.

Develop, optimise, and validate analytical methods for lipids, polymers, and nanoparticle components using:

• HPLC‑CAD
• HPLC‑UV
• LC‑MS

Perform structural and compositional profiling of PEG‑lipids, ionisable lipids, and excipients.

Execute method validation according to ICH Q2 and support transition into cGMP workflows.

Conduct routine and non‑routine analyses: assay, related impurities, stability studies and Endotoxin analysis.

Independently troubleshoot analytical methods and instruments.

Interpret data, prepare reports, and present results to cross‑functional teams.

Support external CROs, CDMOs, and GMP partners as needed.

Contribute to building analytical capability in a growing biotech environment, including SOPs, workflows, and instrument best practices.

REQUIRED QUALIFICATIONS & EXPERIENCE

Master’s degree (MSc or higher) in Chemistry, Analytical Chemistry, Pharmaceutical Sciences or related field.

3+ years hands‑on experience with HPLC in industry (pharma/biotech preferred).

Demonstrated proficiency with HPLC‑CAD (strongly preferred).

Hands‑on experience with LC‑MS for lipid or polymer analysis.

Proven track record of method development (minimum 3–5 methods).

Experience with cGMP method validation (at least 2 methods independently validated).

Prior experience working in a GMP or cGMP analytical lab.

Strong practical skills, autonomy, and troubleshooting abilities.

Excellent documentation practices; familiarity with ICH Q2, Q14, and relevant regulatory guidelines.

Ability to thrive in a fast‑paced, collaborative start‑up environment.

DESIRABLE SKILLS

Experience with lipid nanoparticles (LNPs), PEG‑lipids, polymers, or novel excipients.

Experience with charged aerosol detection optimisation.

Knowledge of DSC, Capillary Electrophoresis (CE), and Bacterial Endotoxin analysis.

Familiarity with raw material qualification and release testing.

The job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities, and activities may change, or new ones may be assigned at any time with or without notice, as per ever‑changing business needs.