Principal Scientist

The Association of Technology, Management and Applied Engineering; Greater London; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading scientific organization in the United Kingdom is seeking a Principal Scientist to lead projects that drive faster and better clinical decisions. This role involves designing and validating assays for clinical studies, managing multiple projects, and ensuring data quality in GCP environments. Ideal candidates possess strong expertise in flow cytometry, data analysis, and have a strong educational background in relevant fields. Join us for an opportunity to grow your technical and leadership skills while making a significant impact in science.

Qualifications

• MSc or equivalent in biomedical science, pharmacology, or related field with computational experience.
• Proven hands-on experience in flow cytometry.
• Strong data analysis skills and ability to communicate scientifically.

Responsibilities

• Design and validate biomarker assays for clinical studies.
• Deliver and interpret scientific data for project teams.
• Ensure regulatory compliance in laboratory setting.

Skills

Flow cytometry

Data analysis

Project management

Cell immunology

Education

MSc or equivalent in biomedical science

PhD in relevant scientific discipline

Tools

Cytek Aurora flow cytometer

OMIQ analysis software

Job description

Principal Scientist

As a Principal Scientist you will lead scientific work that helps teams make faster, better decisions. You will design, validate and execute experiments that support both early and late clinical studies. You will work closely with project teams, laboratory colleagues and external partners. We value clear thinkers who share knowledge, care about quality, and enjoy mentoring others. This role offers strong opportunities to grow your technical and leadership skills while contributing to GSK's mission of uniting science, technology and talent to get ahead of disease together.

Responsibilities include:

• Design, develop and validate robust spectral flow cytometry biomarker assays to support early and late clinical studies.
• Deliver, interpret and communicate complex scientific data to project/program teams within agreed timelines whilst managing multiple projects concurrently.
• Ensure high standards for data quality, record keeping and regulatory compliance in a GCP laboratory setting.
• Support assay transfers and collaborations with external partners and contract research organisations.
• Drive improvements in laboratory workflows, automation and data analysis to increase efficiency and reproducibility.
• Contribute to knowledge sharing across the organisation.

Basic Qualifications & Skills:

• MSc or equivalent practical experience in cell immun, biomedical science, pharmacology or related discipline with a significant computational component OR strong experience in Industry in a similar field having gained an undergraduate degree in one of the disciplines named above.
• Proven hands‑on experience in flow cytometry.
• Demonstrable experience in assay development and optimisation of 18+ colour panels.
• Strong data analysis skills and clear written and verbal communication for scientific audiences.
• Experience working with human biological samples and understanding of relevant safety and ethical requirements.
• Ability to manage multiple projects, prioritise tasks and meet deadlines in a collaborative team environment.

Preferred Qualifications & Skills (not required):

• PhD in a relevant scientific discipline.
• Practical experience with specific platforms such as the Cytek Aurora flow cytometer and OMIQ analysis software.
• Significant and demonstrable experience with computational approaches to high dimensional data analysis.
• Experience with both laboratory and analytical automation.
• Experience of assay validation, working within GCP or other regulated environments and familiarity with relevant regulatory expectations.
• Demonstrated ability to influence cross‑functional teams and provide scientific leadership on projects.

Closing Date for Applications 6th February 2026

We are an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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