CRISPR Screening Scientist – Neurodegeneration & iPSC

Wellcome Genome campus; Hinxton; Hybrid; GBP 40,000 - 49,000; Full time

Job summary

A leading genomics research institute in the United Kingdom seeks a Technical Specialist to explore immune responses to neurodegenerative diseases. This role involves performing large-scale CRISPR screens on iPSC-derived microglia and developing assays to model immune responses. Ideal candidates will have a degree in a relevant field, extensive lab experience, and strong communication skills, contributing to innovative research in diseases like Alzheimer's and Parkinson's. Hybrid working is possible, along with competitive salary and benefits.

Benefits

Flexible working hours

Family and carer-friendly policies

Employee wellbeing strategy

Qualifications

• Extensive practical experience with cell and molecular biology techniques.
• Ability to develop and validate assays for genetic modulation.
• Strong organisational and time management skills.

Responsibilities

• Perform large-scale phenotypic CRISPR screens on human iPSC-derived microglia.
• Collaborate with interdisciplinary teams on immune response assays.
• Integrate data with patient-derived datasets to uncover mechanisms.

Skills

Core techniques in cell biology

Molecular biology techniques

Genome engineering knowledge

Problem-solving skills

Excellent communication skills

Education

Degree in Cell Biology, Neuroscience, Immunology or related field

Tools

CRISPR

Cell culture protocols

Job description

A leading genomics research institute in the United Kingdom seeks a Technical Specialist to explore immune responses to neurodegenerative diseases. This role involves performing large-scale CRISPR screens on iPSC-derived microglia and developing assays to model immune responses. Ideal candidates will have a degree in a relevant field, extensive lab experience, and strong communication skills, contributing to innovative research in diseases like Alzheimer's and Parkinson's. Hybrid working is possible, along with competitive salary and benefits.