Postes à Grenoble, France

ALPX, Grenoble, France

ALPX is an EMBL Spin-off Company located in Grenoble, France (http://alpx-services.com). We offer innovative research services based on the CrystalDirect technology for structural biology and small-molecule drug discovery to the pharmaceutical and biotech industries. Starting in 2025, we will also offer a rapid and agile Single Particle Analysis cryo-Electron Microscopy (SPA cryo-EM) full service, encompassing everything from cryo-EM sample preparation to structure determination.

We seek a highly motivated single-particle cryo-EM specialist to join the ALPX team. The successful candidate will contribute to a range of exciting structural biology and drug discovery projects and participate in the development of our sample-to-solution cryo-EM service, with a particular focus on automating on-the-fly and offline data processing.

Responsibilities:

1. Single-particle data acquisition and analysis.
2. Implementation and optimization of cryo-EM data storage.
3. On-the-fly data processing.
4. High-quality structure elucidation and interpretation.
5. Assist in writing project proposals.
6. Work with various cryo-EM platforms.
7. Travel for data collection.
8. Prepare presentations on structural data for the project team and clients.

Required knowledge, skills, and abilities:

1. Ph.D. in chemistry, biology, physics, or a related field, with an excellent track record.
2. Multiple cryo-EM map/structure depositions and peer-reviewed publications.
3. Strong expertise in a variety of cryo-EM and structural analysis software (i.e., Relion, CryoSPARC, EMAN, CCPEM, Chimera and COOT).
4. Experience in high-resolution structure determination by cryo-EM, including model building from scratch and structure refinement (Cccp4 and Phenix).
5. Scripting experience (Shell, Python).
6. Team player with the ability to work on several projects in parallel.
7. Strong oral and written English communication and organisation skills.

Preferred knowledge, skills, and abilities:

1. Experience in SPA cryo-EM on membrane proteins and epitopes mapping.
2. Experience in Industry/CRO/CMO.
3. Familiarity with HPC and Cloud Platforms.
4. Experience in cryo-electron tomography (Cryo-ET) and sub-tomogram averaging.

The position is permanent and immediately available. Deadline for application: 17.11.2024.

If you are enthusiastic about this position but find that your previous experience does not precisely match every requirement outlined in the job description, we still encourage you to apply. We look forward to hearing from you.