Senior Clinical Scientist – Molecular

ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis.

ANGLE’s Parsortix system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis. Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patient’s tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes.

ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide. In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays.

Join our Team

This is an exciting time at ANGLE and our team in Guildford are looking for a Senior Clinical Scientist – Molecular. The Senior Scientist will have a major role in building a new molecular profiling unit within our clinical laboratory and will use their expertise to assemble a new team and to oversee Biopharma services deployed in the clinical laboratory for the processing and analysis of liquid biopsy samples using validated molecular profiling technologies. This will include DNA and RNA profiling and methylation patterns of circulating tumour cells (CTCs) and cfDNA and will use technologies such as NGS and ddPCR.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

Principal Accountabilities

This position plays a crucial role in facilitating the governance, and management of risk and compliance, under the requirements of Medical Laboratories standard ISO15189:2022 and applicable normative references, with a demonstrable knowledge of interacting with agencies and accreditation bodies such as UKAS, HMRA, HTA and CLIA.

The job holder is expected to work closely with multiple functions across the company, particularly with the R&D assay development team, to ensure timely implementation of high quality, validated molecular assays for deployment in our clinical assay services portfolio.

The job holder will run assays for service clients, analysing data and preparing reports and will also take on the important role of managing client relationships.

Duties will include:

• Management of small team initially with the expectation of further growth
• Remit to set up the clinical molecular profiling lab under the guidance of the Clinical Laboratory Director and implement the relevant technologies ready for the timely transfer of developed assays to the clinical team for the provision of Biopharma client services
• Participate in the validation and running of molecular profiling assays alongside the team
• Work seamlessly across the functions to ensure assays for service contracts are completed on time and to a high standard
• Responsible for ensuring quality and regulatory compliance of all procedures
• Oversee management of allocated data transfer agreements, statements of work, and master service agreements, ensuring delivery is on time
• Establish the required data handling systems for handling complex NGS data and reporting through LIMS
• Monitor operational performance and implement necessary improvements, undertaking periodic reviews of key laboratory systems such as document control, risk management, hazard and precaution management, stock and asset management, staff qualification, business continuity, data and record retention
• Remain abreast of scientific and technical advances, especially in your field of expertise, making recommendations on new processes, technologies and product opportunities

Education, Qualifications and Experience

• PhD in relevant biomedical sciences, with at least 3 years post-doctoral experience or equivalent in oncology and NGS/molecular biology, preferably gained in the area of clinical diagnostic assay development/validation
• HCPC registration as a Clinical Scientist or Biomedical Scientist in a relevant genomic discipline
• Demonstrated expertise and hands-on competency in molecular profiling using NGS and ddPCR in a clinical lab setting
• Ability to analyse complex NGS and clinical data with competency in statistical analysis
• Experience in operating to Medical Laboratories standard ISO15189:2022 and applicable normative references, with a demonstrable knowledge of interacting with agencies and accreditation bodies such as UKAS, HMRA, HTA and CLIA.
• A strong leader with demonstrated ability to manage multidisciplinary teams and possessing a flexible, can-do approach to the requirements of the job
• Excellent scientific/technical aptitude combined with business acumen
• Strong team player with excellent oral and written communication skills
• Ability to coordinate the timely creation and delivery of documents to the required standards
• An eye for detail and commitment to high quality data with the ability to summarize detailed data and form actionable recommendations for a variety of audiences
• Organisational and prioritisation skills in response to unexpected opportunities or risks
• Ability to problem-solve over a complex range of tasks subject to competing contractual, financial, personnel and time constraints
• Continuous learner with a keen appetite for cross-disciplinary work

Job Requirements

This role is based at the Guildford laboratory. Due to the nature of the role, our requirement is for this position to be laboratory-based in Guildford. Some flexibility on working hours may be required and working from home occasionally can be considered at manager’s discretion.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.