Clinical Scientist I, Technology Transfer

ANGLE plc; Guildford; On-site; GBP 30,000 - 50,000; Full time

Job description

ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis.

ANGLE’s Parsortix system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood.

Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis. Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patient’s tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes.

ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide. In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays.

Join our Team

This is an exciting time at ANGLE and our team in Guildford are looking for a Clinical Scientist – Tech Transfer.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

Principal Accountabilities

• Ensure the smooth and seamless transfer of imaging and molecular assays from R&D for implementation in the Clinical Services laboratory
• Perform assay validation and verification to conform to ISO 15189:2022 standards in close co-operation with the Technology Transfer Team, R&D and other functions as required
• Build strong cross-functional relationships, particularly with R&D and the manufacturing team to ensure excellent communication for the complex transfer activities
• Take accountability for ensuring quality and regulatory compliance of all procedures
• Prepare documents as required, always ensuring compliance with the QMS
• Responsible for entering the required assay data into the LIMS
• Review data with manager and relevant teams, obtaining the required sign-off of reports

Qualifications, Experience, Knowledge and Attributes

• BSc in relevant biomedical sciences, with preferably 2 years experience in a clinical laboratory setting
• A high performing scientist, possessing a flexible, can-do approach to the requirements of the job
• Experience in validation and verification of imaging and/or molecular assays for clinical laboratory use
• Ability to analyse complex NGS and imaging clinical data with competency in statistical analysis
• An eye for detail and commitment to generating high quality data, with the ability to co-ordinate the timely creation and delivery of documents to the required standards, and strong organisational skills to maintain compliance with the QMS
• Experience of working with LIMS systems for data management
• Experience in operating to Medical Laboratories standard ISO15189:2022 and applicable normative references, with a demonstrable knowledge of interacting with agencies and accreditation bodies such as UKAS, HMRA, HTA and CLIA would be an advantage
• Strong team player with excellent oral and written communication skills
• Organisational and prioritisation skills in response to unexpected opportunities or risks
• Ability to problem-solve over a complex range of tasks subject to competing contractual, financial, personnel and time constraints
• Continuous learner with a keen appetite for cross-disciplinary work

Job Requirements

Due to the nature of the role, our requirement is for this position to be laboratory-based in Guildford. Some flexibility on working hours may be required and working from home occasionally can be considered at manager’s discretion.

As a member of our highly skilled team, you will receive opportunities for training and development and a competitive benefits package.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.